Why is the use of certain antidepressants controversial during pregnancy?

The use of certain antidepressants during pregnancy is particularly controversial due to the potential for unknown effects on fetal development. During pregnancy, the developing fetus is highly sensitive to various substances, including medications. Antidepressants, especially those belonging to specific classes like selective serotonin reuptake inhibitors (SSRIs), may be associated with risks such as congenital malformations or neurodevelopmental disorders, although definitive evidence is often lacking or inconclusive. This uncertainty necessitates careful consideration and weighing of the benefits of treating maternal depression against the potential risks to the fetus.

In contrast to the correct answer, excessive weight gain is not specifically tied to the use of antidepressants during pregnancy, as weight gain can be influenced by many factors and does not directly relate to fetal risks. The statement that antidepressants are always harmful is overly simplistic and misleading, as many women with untreated depression can experience significant negative outcomes as well. Lastly, while some antidepressants may cause sleepiness or sedation as side effects in the mother, this does not address the primary concern regarding fetal health and development.