Which of the following medications is typically contraindicated in early pregnancy?

Ibuprofen is typically contraindicated in early pregnancy due to its potential to affect fetal development and increase the risk of complications. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can interfere with the synthesis of prostaglandins, which are important for several physiological functions during pregnancy, including maintaining the patency of the ductus arteriosus (an essential blood vessel in the fetus). In the first trimester, the use of ibuprofen may be associated with an increased risk of miscarriage or fetal heart defects.

In contrast, folic acid is essential for reducing the risk of neural tube defects in the developing fetus and is recommended for women trying to conceive and during early pregnancy. Iron supplements are commonly used to prevent or treat anemia, which can be particularly important during pregnancy due to increased maternal blood volume. Calcium tablets are also not contraindicated and can be beneficial for both maternal bone health and fetal bone development. Thus, ibuprofen stands out as the medication that poses potential risks during early pregnancy, making it the correct choice for this question.