Which medication is contraindicated for diabetic pregnant women?

In pregnancy, certain medications can pose risks to both the mother and the developing fetus. ACE inhibitors, which are commonly used to treat hypertension and heart failure, are contraindicated for diabetic pregnant women due to their potential to cause adverse effects on fetal development, particularly during the second and third trimesters. These medications can lead to complications such as renal impairment, pulmonary hypoplasia, and skull ossification issues in the fetus.

On the other hand, insulin is the first-line treatment for diabetes in pregnant women as it does not cross the placenta and is safe for both mother and baby. Metformin is also considered safe and is used to manage gestational diabetes. Glimepiride, while not the first choice, may be used in certain cases, although insulin is preferred. The specific contraindication of ACE inhibitors in pregnancy underscores the importance of carefully selecting medications to ensure the safety of both the mother and the developing fetus.