What is an important consideration when administering Syntocinon with prostaglandins?

The administration of Syntocinon (synthetic oxytocin) alongside prostaglandins requires careful timing because both agents can significantly affect uterine activity. When combined, these medications can enhance each other's uterotonic effects, leading to an increased risk of uterine hyperstimulation. This hyperstimulation can cause adverse outcomes for both the mother and fetus, including fetal distress and uterine rupture in severe cases.

Therefore, it is critical to administer them with adequate intervals, typically at least 6 hours apart, to mitigate the risk of these potential complications. This timing allows one medication to more fully achieve its effects and be metabolized before the second is introduced, ensuring that the contractile activity of the uterus is closely monitored and controlled to ensure safety during labor and delivery.

Though Syntocinon and prostaglandins can technically be administered together, doing so without appropriate timing could lead to serious clinical challenges, which underscores the importance of adhering to the recommended waiting period.