What is a reason NSAIDs should not be used during pregnancy?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with potential risks when administered during pregnancy, particularly concerning the fetal cardiovascular system. One significant reason for avoiding the use of NSAIDs is their ability to cause premature closure of the ductus arteriosus, a vital blood vessel in the fetus that connects the pulmonary artery to the aorta.

During pregnancy, the ductus arteriosus remains open to ensure proper blood circulation and oxygenation in the fetus. If this vessel closes prematurely, it can lead to serious complications, including fetal distress and pulmonary hypertension. This is particularly critical during the third trimester when the risk of this adverse effect is heightened, as the fetus is developing and preparing for transition to postnatal life.

Other options may pose different risks associated with NSAID use, but the premature closure of the ductus arteriosus is a direct and profound concern that underscores why NSAIDs should be avoided in pregnant individuals, particularly during the later stages of pregnancy.