What is a common side effect of Metoclopramide?

Metoclopramide is a medication commonly used to treat nausea and gastroparesis, and it functions as a dopamine receptor antagonist. One of the notable side effects associated with this medication is restlessness, which is often classified as akathisia. This side effect arises from its action on the central nervous system, particularly affecting dopamine pathways that can lead to increased motor activity and subjective feelings of unease or agitation.

Restlessness can be particularly important to monitor in clinical settings, especially when administering metoclopramide to pregnant individuals or those in labor, as it may affect their comfort and overall experience. Understanding the mechanisms by which metoclopramide acts helps to clarify why restlessness can occur, emphasizing the importance of monitoring and managing this side effect in clinical practice.